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ATR(Mec1) Phosphorylation-independent Activation of Chk1 in Vivo
The conserved protein kinase Chk1 is a player in the defense against DNA damage and replication blocks. The current model is that after DNA damage or replication blocks, ATR(Mec1) phosphorylates Chk1 on the non-catalytic C-terminal domain. However, the mechanism of activation of Chk1 and the functio...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2610496/ https://ncbi.nlm.nih.gov/pubmed/18984588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806530200 |
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