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Conserved ATR(Mec1) phosphorylation-independent activation of Chk1 by single amino acid substitution in the GD domain

Chk1 is a conserved kinase that comprises the first line of defense against DNA damage and replication blocks. Chk1 consists of two primary domains, the well conserved N-terminal kinase domain and the non-catalytic C-terminal domain that contains the two highly conserved TRF and GD sub-domains. Seve...

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Detalhes bibliográficos
Main Authors: Pereira, Elizabeth, Chen, Yinhuai, Sanchez, Yolanda
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045630/
https://ncbi.nlm.nih.gov/pubmed/19411848
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