Disruption of Src function potentiates Chk1-inhibitor–induced apoptosis in human multiple myeloma cells in vitro and in vivo

Ras/MEK/ERK pathway activation represents an important compensatory response of human multiple myeloma (MM) cells to checkpoint kinase 1 (Chk1) inhibitors. To investigate the functional roles of Src in this event and potential therapeutic significance, interactions between Src and Chk1 inhibitors (e...

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Detalhes bibliográficos
Main Authors: Dai, Yun, Chen, Shuang, Shah, Rena, Pei, Xin-Yan, Wang, Li, Almenara, Jorge A., Kramer, Lora B., Dent, Paul, Grant, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056642/
https://ncbi.nlm.nih.gov/pubmed/21148814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-06-291146
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