A Bim-targeting strategy overcomes adaptive bortezomib resistance in myeloma through a novel link between autophagy and apoptosis

Bim contributes to resistance to various standard and novel agents. Here we demonstrate that Bim plays a functional role in bortezomib resistance in multiple myeloma (MM) cells and that targeting Bim by combining histone deacetylase inhibitors (HDACIs) with BH3 mimetics (eg, ABT-737) overcomes borte...

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Detalhes bibliográficos
Main Authors: Chen, Shuang, Zhang, Yu, Zhou, Liang, Leng, Yun, Lin, Hui, Kmieciak, Maciej, Pei, Xin-Yan, Jones, Richard, Orlowski, Robert Z., Dai, Yun, Grant, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208284/
https://ncbi.nlm.nih.gov/pubmed/25208888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-03-564534
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