A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

Proteasome inhibitors have demonstrated that targeting protein degradation is effective therapy in multiple myeloma (MM). Here we show that deubiquitylating enzymes (DUBs) USP14 and UCHL5 are more highly expressed in MM cells than in normal plasma cells. USP14 and UCHL5 short interfering RNA knockdo...

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Detalhes bibliográficos
Principais autores: Tian, Ze, D’Arcy, Padraig, Wang, Xin, Ray, Arghya, Tai, Yu-Tzu, Hu, Yiguo, Carrasco, Ruben D., Richardson, Paul, Linder, Stig, Chauhan, Dharminder, Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907756/
https://ncbi.nlm.nih.gov/pubmed/24319254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-05-500033
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