Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells

PURPOSE: The ubiquitin proteasome pathway is a validated therapeutic target in multiple myeloma (MM). Deubiquitylating enzyme USP1 participates in DNA damage response and cellular differentiation pathways. To date, the role of USP1 in MM biology is not defined. In the present study, we investigated...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Das, Deepika Sharma, Das, Abhishek, Ray, Arghya, Song, Yan, Samur, Mehmet Kemal, Munshi, Nikhil C., Chauhan, Dharminder, Anderson, Kenneth C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540781/
https://ncbi.nlm.nih.gov/pubmed/28270494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2692
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