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Proteomic analysis identifies mechanism(s) of overcoming bortezomib resistance via targeting ubiquitin receptor Rpn13

Our prior study showed that inhibition of 19S proteasome-associated ubiquitin receptor Rpn13 can overcome bortezomib resistance in MM cells. Here, we performed proteomic analysis of Rpn13 inhibitor (RA190)-treated MM cells and identified an antioxidant enzyme superoxide dismutase (SOD1) as a mediato...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Du, Ting, Song, Yan, Ray, Arghya, Chauhan, Dharminder, Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988682/
https://ncbi.nlm.nih.gov/pubmed/32424294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-020-0865-2
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