Development and preclinical validation of a novel covalent ubiquitin receptor Rpn13 degrader in multiple myeloma

Proteasome inhibition is an effective treatment for multiple myeloma (MM); however, targeting different components of the ubiquitin–proteasome system (UPS) remains elusive. Our RNA-interference studies identified proteasome-associated ubiquitin-receptor Rpn13 as a mediator of MM cell growth and surv...

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Vydáno v:Leukemia
Hlavní autoři: Song, Yan, Park, Paul M. C., Wu, Lei, Ray, Arghya, Picaud, Sarah, Li, Deyao, Wimalasena, Virangika K., Du, Ting, Filippakopoulos, Panagis, Anderson, Kenneth C., Qi, Jun, Chauhan, Dharminder
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783320/
https://ncbi.nlm.nih.gov/pubmed/30962579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0467-z
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