Development and preclinical validation of a novel covalent ubiquitin receptor Rpn13 degrader in multiple myeloma

Proteasome inhibition is an effective treatment for multiple myeloma (MM); however, targeting different components of the ubiquitin–proteasome system (UPS) remains elusive. Our RNA-interference studies identified proteasome-associated ubiquitin-receptor Rpn13 as a mediator of MM cell growth and surv...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Leukemia
Hauptverfasser: Song, Yan, Park, Paul M. C., Wu, Lei, Ray, Arghya, Picaud, Sarah, Li, Deyao, Wimalasena, Virangika K., Du, Ting, Filippakopoulos, Panagis, Anderson, Kenneth C., Qi, Jun, Chauhan, Dharminder
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783320/
https://ncbi.nlm.nih.gov/pubmed/30962579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0467-z
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge