A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

Proteasome inhibitors have demonstrated that targeting protein degradation is effective therapy in multiple myeloma (MM). Here we show that deubiquitylating enzymes (DUBs) USP14 and UCHL5 are more highly expressed in MM cells than in normal plasma cells. USP14 and UCHL5 short interfering RNA knockdo...

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Bibliographic Details
Main Authors: Tian, Ze, D’Arcy, Padraig, Wang, Xin, Ray, Arghya, Tai, Yu-Tzu, Hu, Yiguo, Carrasco, Ruben D., Richardson, Paul, Linder, Stig, Chauhan, Dharminder, Anderson, Kenneth C.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2014
Subjects:
Lymphoid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907756/
https://ncbi.nlm.nih.gov/pubmed/24319254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-05-500033
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