Intracellular NAD(+) depletion enhances bortezomib-induced anti-myeloma activity

We recently demonstrated that Nicotinamide phosphoribosyltransferase (Nampt) inhibition depletes intracellular NAD(+) content leading, to autophagic multiple myeloma (MM) cell death. Bortezomib has remarkably improved MM patient outcome, but dose-limiting toxicities and development of resistance lim...

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Détails bibliographiques
Auteurs principaux: Cagnetta, Antonia, Cea, Michele, Calimeri, Teresa, Acharya, Chirag, Fulciniti, Mariateresa, Tai, Yu-Tzu, Hideshima, Teru, Chauhan, Dharminder, Zhong, Mike Y., Patrone, Franco, Nencioni, Alessio, Gobbi, Marco, Richardson, Paul, Munshi, Nikhil, Anderson, Kenneth C.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2013
Sujets:
Lymphoid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744991/
https://ncbi.nlm.nih.gov/pubmed/23823317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-02-483511
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