Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells

Multiple myeloma (MM) is characterized by a highly unstable genome, with aneuploidy observed in nearly all patients. The mechanism causing this karyotypic instability is largely unknown, but recent observations have correlated these abnormalities with dysfunctional DNA damage response. Here, we show...

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Pubblicato in:Blood
Autori principali: Cea, Michele, Cagnetta, Antonia, Adamia, Sophia, Acharya, Chirag, Tai, Yu-Tzu, Fulciniti, Mariateresa, Ohguchi, Hiroto, Munshi, Aditya, Acharya, Prakrati, Bhasin, Manoj K., Zhong, Lei, Carrasco, Ruben, Monacelli, Fiammetta, Ballestrero, Alberto, Richardson, Paul, Gobbi, Marco, Lemoli, Roberto M., Munshi, Nikhil, Hideshima, Teru, Nencioni, Alessio, Chauhan, Dharminder, Anderson, Kenneth C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2016
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778164/
https://ncbi.nlm.nih.gov/pubmed/26675349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-06-649970
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