Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells

Multiple myeloma (MM) is characterized by a highly unstable genome, with aneuploidy observed in nearly all patients. The mechanism causing this karyotypic instability is largely unknown, but recent observations have correlated these abnormalities with dysfunctional DNA damage response. Here, we show...

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Vydáno v:Blood
Hlavní autoři: Cea, Michele, Cagnetta, Antonia, Adamia, Sophia, Acharya, Chirag, Tai, Yu-Tzu, Fulciniti, Mariateresa, Ohguchi, Hiroto, Munshi, Aditya, Acharya, Prakrati, Bhasin, Manoj K., Zhong, Lei, Carrasco, Ruben, Monacelli, Fiammetta, Ballestrero, Alberto, Richardson, Paul, Gobbi, Marco, Lemoli, Roberto M., Munshi, Nikhil, Hideshima, Teru, Nencioni, Alessio, Chauhan, Dharminder, Anderson, Kenneth C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2016
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778164/
https://ncbi.nlm.nih.gov/pubmed/26675349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-06-649970
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