Disruption of IκB Kinase (IKK)-mediated RelA Serine 536 Phosphorylation Sensitizes Human Multiple Myeloma Cells to Histone Deacetylase (HDAC) Inhibitors

Post-translational modifications of RelA play an important role in regulation of NF-κB activation. We previously demonstrated that in malignant hematopoietic cells, histone deacetylase inhibitors (HDACIs) induced RelA hyperacetylation and NF-κB activation, attenuating lethality. We now present evide...

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Detalhes bibliográficos
Main Authors: Dai, Yun, Chen, Shuang, Wang, Li, Pei, Xin-Yan, Funk, Vanessa L., Kramer, Lora B., Dent, Paul, Grant, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190767/
https://ncbi.nlm.nih.gov/pubmed/21816815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.284216
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