Mcl-1 Inhibition: Managing Malignancy in Multiple Myeloma

Multiple myeloma (MM) is a plasma cells neoplasm. The overexpression of Bcl-2 family proteins, particularly myeloid cell leukemia 1 (Mcl-1), plays a critical role in the pathogenesis of MM. The overexpression of Mcl-1 is associated with drug resistance and overall poor prognosis of MM. Thus, inhibit...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Al-Odat, Omar S., von Suskil, Max, Chitren, Robert J., Elbezanti, Weam O., Srivastava, Sandeep K., Budak-Alpddogan, Tulin, Jonnalagadda, Subash C., Aggarwal, Bharat B., Pandey, Manoj
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8327170/
https://ncbi.nlm.nih.gov/pubmed/34349655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.699629
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