Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor–induced DNA damage in vitro and in vivo in human multiple myeloma cells

The role of the Ras/MEK/ERK pathway was examined in relation to DNA damage in human multiple myeloma (MM) cells exposed to Chk1 inhibitors in vitro and in vivo. Exposure of various MM cells to marginally toxic concentrations of the Chk1 inhibitors UCN-01 or Chk1i modestly induced DNA damage, accompa...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Dai, Yun, Chen, Shuang, Pei, Xin-Yan, Almenara, Jorge A., Kramer, Lora B., Venditti, Charis A., Dent, Paul, Grant, Steven
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2008
Sujets:
Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532812/
https://ncbi.nlm.nih.gov/pubmed/18614762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-05-159392
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires