Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

[Image: see text] G-protein coupled receptors (GPCRs) are the primary target class of currently marketed drugs, accounting for about a quarter of all drug targets of approved medicines. However, almost all the screening efforts for novel ligand discovery rely exclusively on cellular systems overexpr...

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Autori principali: Aristotelous, Tonia, Ahn, Seungkirl, Shukla, Arun K., Gawron, Sylwia, Sassano, Maria F., Kahsai, Alem W., Wingler, Laura M., Zhu, Xiao, Tripathi-Shukla, Prachi, Huang, Xi-Ping, Riley, Jennifer, Besnard, Jérémy, Read, Kevin D., Roth, Bryan L., Gilbert, Ian H., Hopkins, Andrew L., Lefkowitz, Robert J., Navratilova, Iva
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2013
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892729/
https://ncbi.nlm.nih.gov/pubmed/24454993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400312j
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