Discovery of an in vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP

Among epigenetic “writers”, “readers”, and “erasers”, the lysine methyltransferases G9a and GLP, which catalyze mono- and dimethylation of histone H3 lysine 9 (H3K9me2) and non-histone proteins, have been implicated in a variety of human diseases. A “toolkit” of well-characterized chemical probes wi...

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Main Authors: Liu, Feng, Barsyte-Lovejoy, Dalia, Li, Fengling, Xiong, Yan, Korboukh, Victoria, Huang, Xi-Ping, Allali-Hassani, Abdellah, Janzen, William P., Roth, Bryan L., Frye, Stephen V., Arrowsmith, Cheryl H., Brown, Peter J., Vedadi, Masoud, Jin, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880643/
https://ncbi.nlm.nih.gov/pubmed/24102134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401480r
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