Discovery of an in vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP

Among epigenetic “writers”, “readers”, and “erasers”, the lysine methyltransferases G9a and GLP, which catalyze mono- and dimethylation of histone H3 lysine 9 (H3K9me2) and non-histone proteins, have been implicated in a variety of human diseases. A “toolkit” of well-characterized chemical probes wi...

Full description

Saved in:
Bibliographic Details
Main Authors: Liu, Feng, Barsyte-Lovejoy, Dalia, Li, Fengling, Xiong, Yan, Korboukh, Victoria, Huang, Xi-Ping, Allali-Hassani, Abdellah, Janzen, William P., Roth, Bryan L., Frye, Stephen V., Arrowsmith, Cheryl H., Brown, Peter J., Vedadi, Masoud, Jin, Jian
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880643/
https://ncbi.nlm.nih.gov/pubmed/24102134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401480r
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items