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(Biphenyl-4-yl)methylammonium Chlorides: Potent Anticonvulsants That Modulate Na(+) Currents

We have reported that compounds containing a bi-aryl linked unit (Ar-X-Ar′) modulated Na(+) currents by promoting slow inactivation and fast inactivation processes and by inducing frequency (use)-dependent inhibition of Na(+) currents. These electrophysiological properties have been associated with...

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Autori principali: Lee, Hyosung, Park, Ki Duk, Yang, Xiao-Fang, Dustrude, Erik T., Wilson, Sarah M., Khanna, Rajesh, Kohn, Harold
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842382/
https://ncbi.nlm.nih.gov/pubmed/23772678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4007092
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