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Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds

A head-to-head study of representative examples of N-hydroxyindole-2-carboxylates (NHI) and malonic derivatives (Mal) as LDH-A inhibitors was conducted, comparing enzyme inhibition potency, cellular uptake, reduction of lactate production in cancer cells and anti-proliferative activity. Among the co...

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Detaylı Bibliyografya
Asıl Yazarlar: Granchi, Carlotta, Calvaresi, Emilia C., Tuccinardi, Tiziano, Paterni, Ilaria, Macchia, Marco, Martinelli, Adriano, Hergenrother, Paul J., Minutolo, Filippo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828658/
https://ncbi.nlm.nih.gov/pubmed/23986182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3ob40870a
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