Effects of Dimethylarginine Dimethylaminohydrolase–1 Overexpression on the Response of the Pulmonary Vasculature to Hypoxia

Acute and sustained hypoxic pulmonary vasoconstriction (HPV), as well as chronic pulmonary hypertension (PH), is modulated by nitric oxide (NO). NO synthesis can be decreased by asymmetric dimethylarginine (ADMA), which is degraded by dimethylarginine dimethylaminohydrolase–1 (DDAH1). We investigate...

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Detalhes bibliográficos
Main Authors: Bakr, Adel, Pak, Oleg, Taye, Ashraf, Hamada, Farid, Hemeida, Ramadan, Janssen, Wiebke, Gierhardt, Mareike, Ghofrani, Hossein A., Seeger, Werner, Grimminger, Friedrich, Schermuly, Ralph T., Witzenrath, Martin, Brandes, Ralf P., Huang, Ngan, Cooke, John P., Weissmann, Norbert, Sommer, Natascha
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824049/
https://ncbi.nlm.nih.gov/pubmed/23642043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0330OC
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