Effects of Dimethylarginine Dimethylaminohydrolase–1 Overexpression on the Response of the Pulmonary Vasculature to Hypoxia

Acute and sustained hypoxic pulmonary vasoconstriction (HPV), as well as chronic pulmonary hypertension (PH), is modulated by nitric oxide (NO). NO synthesis can be decreased by asymmetric dimethylarginine (ADMA), which is degraded by dimethylarginine dimethylaminohydrolase–1 (DDAH1). We investigate...

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主要な著者: Bakr, Adel, Pak, Oleg, Taye, Ashraf, Hamada, Farid, Hemeida, Ramadan, Janssen, Wiebke, Gierhardt, Mareike, Ghofrani, Hossein A., Seeger, Werner, Grimminger, Friedrich, Schermuly, Ralph T., Witzenrath, Martin, Brandes, Ralf P., Huang, Ngan, Cooke, John P., Weissmann, Norbert, Sommer, Natascha
フォーマット: Artigo
言語:Inglês
出版事項: American Thoracic Society 2013
主題:
Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824049/
https://ncbi.nlm.nih.gov/pubmed/23642043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0330OC
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