Effects of Dimethylarginine Dimethylaminohydrolase–1 Overexpression on the Response of the Pulmonary Vasculature to Hypoxia

Acute and sustained hypoxic pulmonary vasoconstriction (HPV), as well as chronic pulmonary hypertension (PH), is modulated by nitric oxide (NO). NO synthesis can be decreased by asymmetric dimethylarginine (ADMA), which is degraded by dimethylarginine dimethylaminohydrolase–1 (DDAH1). We investigate...

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Main Authors: Bakr, Adel, Pak, Oleg, Taye, Ashraf, Hamada, Farid, Hemeida, Ramadan, Janssen, Wiebke, Gierhardt, Mareike, Ghofrani, Hossein A., Seeger, Werner, Grimminger, Friedrich, Schermuly, Ralph T., Witzenrath, Martin, Brandes, Ralf P., Huang, Ngan, Cooke, John P., Weissmann, Norbert, Sommer, Natascha
Formato: Artigo
Idioma:Inglês
Publicado: American Thoracic Society 2013
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824049/
https://ncbi.nlm.nih.gov/pubmed/23642043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0330OC
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