Effects of Dimethylarginine Dimethylaminohydrolase–1 Overexpression on the Response of the Pulmonary Vasculature to Hypoxia

Acute and sustained hypoxic pulmonary vasoconstriction (HPV), as well as chronic pulmonary hypertension (PH), is modulated by nitric oxide (NO). NO synthesis can be decreased by asymmetric dimethylarginine (ADMA), which is degraded by dimethylarginine dimethylaminohydrolase–1 (DDAH1). We investigate...

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Hauptverfasser: Bakr, Adel, Pak, Oleg, Taye, Ashraf, Hamada, Farid, Hemeida, Ramadan, Janssen, Wiebke, Gierhardt, Mareike, Ghofrani, Hossein A., Seeger, Werner, Grimminger, Friedrich, Schermuly, Ralph T., Witzenrath, Martin, Brandes, Ralf P., Huang, Ngan, Cooke, John P., Weissmann, Norbert, Sommer, Natascha
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Thoracic Society 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824049/
https://ncbi.nlm.nih.gov/pubmed/23642043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0330OC
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