Effects of Dimethylarginine Dimethylaminohydrolase–1 Overexpression on the Response of the Pulmonary Vasculature to Hypoxia

Acute and sustained hypoxic pulmonary vasoconstriction (HPV), as well as chronic pulmonary hypertension (PH), is modulated by nitric oxide (NO). NO synthesis can be decreased by asymmetric dimethylarginine (ADMA), which is degraded by dimethylarginine dimethylaminohydrolase–1 (DDAH1). We investigate...

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Autores principales: Bakr, Adel, Pak, Oleg, Taye, Ashraf, Hamada, Farid, Hemeida, Ramadan, Janssen, Wiebke, Gierhardt, Mareike, Ghofrani, Hossein A., Seeger, Werner, Grimminger, Friedrich, Schermuly, Ralph T., Witzenrath, Martin, Brandes, Ralf P., Huang, Ngan, Cooke, John P., Weissmann, Norbert, Sommer, Natascha
Formato: Artigo
Lenguaje:Inglês
Publicado: American Thoracic Society 2013
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824049/
https://ncbi.nlm.nih.gov/pubmed/23642043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0330OC
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