Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

Despite substantial efforts to understand the interactions between nanoparticles and cells, the cellular processes that determine the efficiency of intracellular drug delivery remain largely unclear. Here we examined cellular uptake of siRNA delivered in lipid nanoparticles (LNPs) using cellular tra...

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Hauptverfasser: Sahay, Gaurav, Querbes, William, Alabi, Christopher, Eltoukhy, Ahmed, Sarkar, Sovan, Zurenko, Christopher, Karagiannis, Emannouil, Love, Kevin, Chen, Delai, Zoncu, Roberto, Buganim, Yosef, Schroeder, Avi, Langer, Robert, Anderson, Daniel G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814166/
https://ncbi.nlm.nih.gov/pubmed/23792629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2614
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