Synergistic Silencing: Combinations of Lipid-like Materials for Efficacious siRNA Delivery

Despite the promise of RNA interference (RNAi) therapeutics, progress toward the clinic has been slowed by the difficulty of delivering short interfering RNA (siRNA) into cellular targets within the body. Nearly all siRNA delivery vehicles developed to date employ a single cationic or ionizable mate...

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Detalhes bibliográficos
Main Authors: Whitehead, Kathryn A, Sahay, Gaurav, Li, George Z, Love, Kevin T, Alabi, Christopher A, Ma, Minglin, Zurenko, Christopher, Querbes, William, Langer, Robert S, Anderson, Daniel G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182356/
https://ncbi.nlm.nih.gov/pubmed/21750531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.141
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