Inhibition of p300 impairs Foxp3(+) T-regulatory cell function and promotes anti-tumor immunity

Foxp3(+) T-regulatory (T(reg)) cells maintain immune homeostasis and limit autoimmunity, but can also curtail host immune responses to various types of tumors(1,2). Foxp3(+) T(regs) are therefore considered promising targets to enhance anti-tumor immunity, and efforts are underway to develop approac...

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Detalhes bibliográficos
Main Authors: Liu, Yujie, Wang, Liqing, Predina, Jarrod, Han, Rongxiang, Beier, Ulf H., Wang, Liang-Chuan S., Kapoor, Veena, Bhatti, Tricia R., Akimova, Tatiana, Singhal, Sunil, Brindle, Paul K., Cole, Philip A., Albelda, Steven M., Hancock, Wayne W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793393/
https://ncbi.nlm.nih.gov/pubmed/23955711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3286
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