Targeting Sirtuin-1 Alleviates Experimental Autoimmune Colitis by Induction of Foxp3+ T-Regulatory Cells: Sirt1 targeting alleviates autoimmune colitis

Induced Foxp3(+) T-regulatory cells (iTreg) are essential to gastrointestinal immune homeostasis and loss of the ability to develop iTregs may lead to autoimmune colitis. We previously showed a role for Sirtuin-1 (Sirt1) in control of Treg function and hypothesized that targeting of Sirt1 might enha...

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Detalhes bibliográficos
Main Authors: Akimova, Tatiana, Xiao, Haiyan, Liu, Yujie, Bhatti, Tricia R., Jiao, Jing, Eruslanov, Evgeniy, Singhal, Sunil, Wang, Liqing, Han, Rongxiang, Zacharia, Keziah, Hancock, Wayne W., Beier, Ulf H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138288/
https://ncbi.nlm.nih.gov/pubmed/24549276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2014.10
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