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Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity

Protocols to use Foxp3+ T-regulatory (Treg) cells for cellular therapy, especially postallogeneic stem cell transplantation, are currently being developed and tested by various groups. Inhibitors of DNA methyltransferase (Dnmt) enzymes have been advocated as a means to promote and stabilize Foxp3 ex...

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Detalhes bibliográficos
Main Authors: Wang, Liqing, Liu, Yujie, Beier, Ulf H., Han, Rongxiang, Bhatti, Tricia R., Akimova, Tatiana, Hancock, Wayne W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643763/
https://ncbi.nlm.nih.gov/pubmed/23444399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-451765
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