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Histone Deacetylases 6 and 9 and Sirtuin-1 Control Foxp3(+) Regulatory T Cell Function Through Shared and Isotype-Specific Mechanisms
Therapeutic targeting of histone/protein deacetylase 6 (HDAC6), HDAC9, or the sirtuin-1 (Sirt1) augments the suppressive functions of regulatory T cells (Tregs) that contain the transcription factor Foxp3. However, it is unclear whether distinct mechanisms are involved or whether combined inhibition...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3603571/ https://ncbi.nlm.nih.gov/pubmed/22715468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002873 |
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