Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation

Sirt3 is an NAD(+)-dependent deacetylase that regulates mitochondrial function by targeting metabolic enzymes and proteins. In fasting mice, Sirt3 expression is decreased in skeletal muscle resulting in increased mitochondrial protein acetylation. Deletion of Sirt3 led to impaired glucose oxidation...

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Detalhes bibliográficos
Main Authors: Jing, Enxuan, O’Neill, Brian T., Rardin, Matthew J., Kleinridders, André, Ilkeyeva, Olga R., Ussar, Siegfried, Bain, James R., Lee, Kevin Y., Verdin, Eric M., Newgard, Christopher B., Gibson, Bradford W., Kahn, C. Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781465/
https://ncbi.nlm.nih.gov/pubmed/23835326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1650
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