SIRT3 regulates fatty acid oxidation via reversible enzyme deacetylation

Sirtuins are NAD(+)-dependent protein deacetylases and mediate adaptive responses to a variety of stresses, including calorie restriction and metabolic stress. Sirtuin 3 (SIRT3) is localized in the mitochondrial matrix where it regulates the acetylation levels of metabolic enzymes, including acetyl...

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Autori principali: Hirschey, Matthew D., Shimazu, Tadahiro, Goetzman, Eric, Jing, Enxuan, Schwer, Bjoern, Lombard, David B., Grueter, Carrie A., Harris, Charles, Biddinger, Sudha, Ilkayeva, Olga R., Stevens, Robert D., Li, Yu, Saha, Asish K., Ruderman, Neil B., Bain, James R., Newgard, Christopher B., Farese, Robert V., Alt, Frederick W., Kahn, C. Ronald, Verdin, Eric
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841477/
https://ncbi.nlm.nih.gov/pubmed/20203611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08778
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