SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2

SIRT1 and SIRT3 are NAD+-dependent protein deacetylases that are evolutionarily conserved across mammals. These proteins are located in the cytoplasm/nucleus and mitochondria, respectively. Previous reports demonstrated that human SIRT1 deacetylates Acetyl-CoA Synthase 1 (AceCS1) in the cytoplasm, w...

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Hlavní autoři: Hirschey, Matthew D., Shimazu, Tadahiro, Capra, John A., Pollard, Katherine S., Verdin, Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2011
Témata:
Research Perspective
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164371/
https://ncbi.nlm.nih.gov/pubmed/21701047
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