SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production

The mitochondrial sirtuin SIRT3 regulates metabolic homeostasis during fasting and calorie restriction. We identified mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 (HMGCS2) as an acetylated protein and a possible target of SIRT3 in a proteomics survey in hepatic mitochondria from Sirt3(−/−...

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Detalhes bibliográficos
Main Authors: Shimazu, Tadahiro, Hirschey, Matthew D., Hua, Lan, Dittenhafer-Reed, Kristin E., Schwer, Bjoern, Lombard, David B., Li, Yu, Bunkenborg, Jakob, Alt, Frederick W., Denu, John M., Jacobson, Matthew P., Verdin, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310379/
https://ncbi.nlm.nih.gov/pubmed/21109197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.11.003
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