Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

We report that human acetyl-CoA synthetase 2 (AceCS2) is a mitochondrial matrix protein. AceCS2 is reversibly acetylated at Lys-642 in the active site of the enzyme. The mitochondrial sirtuin SIRT3 interacts with AceCS2 and deacetylates Lys-642 both in vitro and in vivo. Deacetylation of AceCS2 by S...

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Bibliografiska uppgifter
Huvudupphovsmän: Schwer, Bjoern, Bunkenborg, Jakob, Verdin, Regis O., Andersen, Jens S., Verdin, Eric
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2006
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502439/
https://ncbi.nlm.nih.gov/pubmed/16788062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603968103
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