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Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2
We report that human acetyl-CoA synthetase 2 (AceCS2) is a mitochondrial matrix protein. AceCS2 is reversibly acetylated at Lys-642 in the active site of the enzyme. The mitochondrial sirtuin SIRT3 interacts with AceCS2 and deacetylates Lys-642 both in vitro and in vivo. Deacetylation of AceCS2 by S...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1502439/ https://ncbi.nlm.nih.gov/pubmed/16788062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603968103 |
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