Sirtuin 3 (SIRT3) Protein Regulates Long-chain Acyl-CoA Dehydrogenase by Deacetylating Conserved Lysines Near the Active Site

Long-chain acyl-CoA dehydrogenase (LCAD) is a key mitochondrial fatty acid oxidation enzyme. We previously demonstrated increased LCAD lysine acetylation in SIRT3 knockout mice concomitant with reduced LCAD activity and reduced fatty acid oxidation. To study the effects of acetylation on LCAD and de...

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Detalhes bibliográficos
Main Authors: Bharathi, Sivakama S., Zhang, Yuxun, Mohsen, Al-Walid, Uppala, Radha, Balasubramani, Manimalha, Schreiber, Emanuel, Uechi, Guy, Beck, Megan E., Rardin, Matthew J., Vockley, Jerry, Verdin, Eric, Gibson, Bradford W., Hirschey, Matthew D., Goetzman, Eric S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837126/
https://ncbi.nlm.nih.gov/pubmed/24121500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.510354
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