SIRT3 and SIRT5 Regulate the Enzyme Activity and Cardiolipin Binding of Very Long-Chain Acyl-CoA Dehydrogenase

SIRT3 and SIRT5 have been shown to regulate mitochondrial fatty acid oxidation but the molecular mechanisms behind the regulation are lacking. Here, we demonstrate that SIRT3 and SIRT5 both target human very long-chain acyl-CoA dehydrogenase (VLCAD), a key fatty acid oxidation enzyme. SIRT3 deacetyl...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhang, Yuxun, Bharathi, Sivakama S., Rardin, Matthew J., Uppala, Radha, Verdin, Eric, Gibson, Bradford W., Goetzman, Eric S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374878/
https://ncbi.nlm.nih.gov/pubmed/25811481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122297
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