Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain

SIRT5 is a lysine desuccinylase known to regulate mitochondrial fatty acid oxidation and the urea cycle. Here, SIRT5 was observed to bind to cardiolipin via an amphipathic helix on its N terminus. In vitro, succinyl-CoA was used to succinylate liver mitochondrial membrane proteins. SIRT5 largely rev...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Zhang, Yuxun, Bharathi, Sivakama S., Rardin, Matthew J., Lu, Jie, Maringer, Katherine V., Sims-Lucas, Sunder, Prochownik, Edward V., Gibson, Bradford W., Goetzman, Eric S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2017
Onderwerpen:
Metabolism
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473227/
https://ncbi.nlm.nih.gov/pubmed/28458255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.785022
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