Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice

Medium-chain triglycerides (MCT), containing C(8)–C(12) fatty acids, are used to treat several pediatric disorders and are widely consumed as a nutritional supplement. Here, we investigated the role of the sirtuin deacylase Sirt5 in MCT metabolism by feeding Sirt5 knockout mice (Sirt5KO) high-fat di...

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發表在:Sci Rep
Main Authors: Goetzman, Eric S., Bharathi, Sivakama S., Zhang, Yuxun, Zhao, Xue-Jun, Dobrowolski, Steven F., Peasley, Kevin, Sims-Lucas, Sunder, Monga, Satdarshan P.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7591893/
https://ncbi.nlm.nih.gov/pubmed/33110171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-75615-3
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