Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI

BACKGROUND: The primary site of damage during AKI, proximal tubular epithelial cells, are highly metabolically active, relying on fatty acids to meet their energy demands. These cells are rich in mitochondria and peroxisomes, the two organelles that mediate fatty acid oxidation. Emerging evidence sh...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Chiba, Takuto, Peasley, Kevin D., Cargill, Kasey R., Maringer, Katherine V., Bharathi, Sivakama S., Mukherjee, Elina, Zhang, Yuxun, Holtz, Anja, Basisty, Nathan, Yagobian, Shiva D., Schilling, Birgit, Goetzman, Eric S., Sims-Lucas, Sunder
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2019
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900790/
https://ncbi.nlm.nih.gov/pubmed/31575700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019020163
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