Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI

BACKGROUND: The primary site of damage during AKI, proximal tubular epithelial cells, are highly metabolically active, relying on fatty acids to meet their energy demands. These cells are rich in mitochondria and peroxisomes, the two organelles that mediate fatty acid oxidation. Emerging evidence sh...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Chiba, Takuto, Peasley, Kevin D., Cargill, Kasey R., Maringer, Katherine V., Bharathi, Sivakama S., Mukherjee, Elina, Zhang, Yuxun, Holtz, Anja, Basisty, Nathan, Yagobian, Shiva D., Schilling, Birgit, Goetzman, Eric S., Sims-Lucas, Sunder
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2019
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900790/
https://ncbi.nlm.nih.gov/pubmed/31575700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019020163
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