Sirt5 Is an NAD-Dependent Protein Lysine Demalonylase and Desuccinylase()

Sirtuins are NAD-dependent deacetylases that regulate important biological processes. Mammals have seven sirtuins, Sirt1-7. Four of them (Sirt4-7) have no detectable or very weak deacetylase activity. Here we found that Sirt5 is an efficient protein lysine desuccinylase and demalonylase in vitro. Th...

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Detalhes bibliográficos
Main Authors: Du, Jintang, Zhou, Yeyun, Su, Xiaoyang, Yu, Jiu Jiu, Khan, Saba, Jiang, Hong, Kim, Jungwoo, Woo, Jimin, Kim, Jun Huyn, Choi, Brian Hyun, He, Bin, Chen, Wei, Zhang, Sheng, Cerione, Richard A., Auwerx, Johan, Hao, Quan, Lin, Hening
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217313/
https://ncbi.nlm.nih.gov/pubmed/22076378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1207861
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