Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5

[Image: see text] NAD(+)-dependent histone deacetylases (sirtuins) play important roles in epigenetic regulation but also through nonhistone substrates for other key cellular events and have been linked to the pathogenesis of cancer, neurodegeneration, and metabolic diseases. The subtype Sirt5 has b...

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Detalhes bibliográficos
Main Authors: Maurer, Benjamin, Rumpf, Tobias, Scharfe, Michael, Stolfa, Diana A., Schmitt, Martin L., He, Wenjuan, Verdin, Eric, Sippl, Wolfgang, Jung, Manfred
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025838/
https://ncbi.nlm.nih.gov/pubmed/24900427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3002709
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