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New chemical tools for probing activity and inhibition of the NAD(+)-dependent lysine deacylase sirtuin 2
Sirtuins are NAD(+)-dependent protein deacylases capable of cleaving off acetyl as well as other acyl groups from the ɛ-amino group of lysines in histones and other substrate proteins. They have been reported as promising drug targets, and thus modulators of their activity are needed as molecular to...
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| Publicado no: | Philos Trans R Soc Lond B Biol Sci |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5915722/ https://ncbi.nlm.nih.gov/pubmed/29685963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2017.0083 |
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