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Targeting SIRT1 to improve metabolism: all you need is NAD(+)?
SIRT1 is an evolutionary conserved NAD(+)-dependent deacetylase that is at the pinnacle of metabolic control, all the way from yeast to humans. SIRT1 senses changes in intracellular NAD(+) levels, which reflect energy level, and uses this information to adapt the cellular energy output, such that th...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3616312/ https://ncbi.nlm.nih.gov/pubmed/22106091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/pr.110.003905 |
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