Sirt6 regulates TNFα secretion via hydrolysis of long chain fatty acyl lysine

The Sir2 family of enzymes or sirtuins are known as nicotinamide adenine dinucleotide (NAD)-dependent deacetylases(1) and have been implicated in the regulation of transcription, genome stability, metabolism, and lifespan(2, 3). However, four of the seven mammalian sirtuins have very weak deacetylas...

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Main Authors: Jiang, Hong, Khan, Saba, Wang, Yi, Charron, Guillaume, He, Bin, Sebastian, Carlos, Du, Jintang, Kim, Ray, Ge, Eva, Mostoslavsky, Raul, Hang, Howard C., Hao, Quan, Lin, Hening
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635073/
https://ncbi.nlm.nih.gov/pubmed/23552949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12038
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