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SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

Mitochondria play a central role in oxidative energy metabolism and age-related diseases such as cancer. Accumulation of spurious oxidative damage can cause cellular dysfunction. Antioxidant pathways that rely on NADPH are needed for the reduction of glutathione and maintenance of proper redox statu...

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Detalhes bibliográficos
Main Authors: Yu, Wei, Dittenhafer-Reed, Kristin E., Denu, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340192/
https://ncbi.nlm.nih.gov/pubmed/22416140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.355206
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