SIRT3 and GCN5L regulation of NADP+- and NADPH-driven reactions of mitochondrial isocitrate dehydrogenase IDH2

Wild type mitochondrial isocitrate dehydrogenase (IDH2) was previously reported to produce oncometabolite 2-hydroxyglutarate (2HG). Besides, mitochondrial deacetylase SIRT3 has been shown to regulate the oxidative function of IDH2. However, regulation of 2HG formation by SIRT3-mediated deacetylation...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Smolková, Katarína, Špačková, Jitka, Gotvaldová, Klára, Dvořák, Aleš, Křenková, Alena, Hubálek, Martin, Holendová, Blanka, Vítek, Libor, Ježek, Petr
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250847/
https://ncbi.nlm.nih.gov/pubmed/32457458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65351-z
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