Biochemical Background in Mitochondria Affects 2HG Production by IDH2 and ADHFE1 in Breast Carcinoma

SIMPLE SUMMARY: 2-hydroxyglutarate (2HG) is a metabolite resembling normal cell metabolite 2-oxoglutarate (2OG), however, its accumulation in cells might lead to amplification of processes in cancer development. R-2HG is a product or bi-product of several metabolic enzymes, including mitochondrial o...

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Publicat a:Cancers (Basel)
Autors principals: Špačková, Jitka, Gotvaldová, Klára, Dvořák, Aleš, Urbančoková, Alexandra, Pospíšilová, Kateřina, Větvička, David, Leguina-Ruzzi, Alberto, Tesařová, Petra, Vítek, Libor, Ježek, Petr, Smolková, Katarína
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8038481/
https://ncbi.nlm.nih.gov/pubmed/33916579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13071709
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